This collection consists of a single, four-page letter written by Charles Newtin Denison, a student at Cincinnati College of Medicine and Surgery. Written on Union patriotic stationery, the letter is dated Cincinnati, Ohio, December 22, 1861, and is addressed to "Brother Willmore." Denison writes that he is busy with the second course of classes in medical school and notes that his is a "fine looking class of young men" with "not a drunken one in the class." Denison writes briefly of the class's experiences in dissecting cadavers, and he reports seeing many operations performed, including a recent one in which chloroform was employed. He concludes with a few words about the upcoming Christmas vacation, writing that he "will not have time to get tite [sic]" as he will be working on his thesis.