The Huff-Hylton Families Papers consists of items from the early 1800s through the American Civil War pertaining to the business and personal lives of Samuel Huff, Lorenzo Dow Hylton, and their families in Montgomery (now Floyd) County, Virginia. Materials include promissory notes, correspondence, an indenture for land, and genealogical information.

Items from the early 1800s pertaining to the business dealings of Samuel Huff include promissory notes, fines for Huff's failure to attend muster of the 75th Regiment of the Virginia Militia, and an indenture for land.

The collection also consists of six letters written by Lorenzo Dow Hylton to his wife Barbara while he served in Company D of the 54th Virginia Infantry during the Civil War, and one letter to him from Barbara. Included in the collection are letters from Barbara's cousin, Samuel Slusher, and brother-in-law, Ira Hylton, about Lorenzo Hylton's death in a Confederate hospital in Marietta, Georgia, and letters from Martha Huff of Indiana, to Barbara.

Genealogical information about the Hylton family, compiled by a descendent of the family, is also a part of the collection.