This collection contains materials related to the Mercury, Gemini, and Apollo space exploration programs of the National Aeronautics and Space Administration (NASA). Containing mostly technical data on spacecraft systems design and operation, the collection provides a detailed look at NASA systems engineering during the early to mid 1960s. The collection is divided among the following series:

Series I: NASA Programs, 1963-1967, n.d., contains in-house technical publications detailing spacecraft systems design and procedures and is divided among three subseries. Together, these subseries chronicle the development and evolution of spacecraft systems design and procedures which culminated in the first lunar landing.

Subseries A: Project Mercury, 1963, n.d., contains one technical report and an historical overview of the program.

Subseries B: Project Gemini, 1963-1966, n.d., is much more extensive, and includes such items as operations handbooks, systems diagrams, briefing outlines, reports and mission simulator manuals.

Subseries C: Project Apollo, 1964-1967, n.d., contains similar materials, in addition to spacecraft manuals, study guides and charts.

Series II: NASA Computer Systems, 1962-1966, n.d., includes programmer manuals for the various computer systems used by NASA during the Mercury, Gemini and Apollo programs. The majority of the materials in this series concern the DDP general computer system.

Series III: NASA Public Information, 1962-1991, n.d., consists of materials which were produced for public education, unlike the previous series. The series contains NASA Fact Sheets and NASA Educational Briefs, other general public information booklets, a symposium report and a set of astronaut photo portraits, all produced to familiarize the public with NASA's activities, personnel and facilities.

Series IV: General Materials, 1969-2001, n.d., contains materials related to space exploration but not produced by NASA. The series includes magazine articles and a "Sounds of Space" recording.