The Stanford E. Chaillé Collection consists of letters, government-issued documents, printed material, and two photo albums containing thirty-six photos. Those pictured in photos include: Dr. Chaillé, Laura Chaillé, Mr. and Mrs. Thomas Layton M. D. P., and other friends. Materials date from shortly before the American Civil War to the decades following southern Reconstruction. Salient topics are the occupation of New Orleans by the Union during the Civil War, postwar government elections, the great yellow fever epidemic, and Dr. Chaillé's long career and accolades. Several documents relate to Dr. Chaillé's position as dean of the Tulane Medical School, such as a notable graduation speech welcoming Confederate leader Jefferson Davis. Dr. Chaillé's interest in genealogical research also appears in letters and documents. In one genealogical sketch, Dr. Chaillé traces his family tree to France where it was "very Catholic" before 1540.