The Yellow Sulphur Springs resort, located between the towns of Blacksburg and Christiansburg, Virginia, commenced operation as a health spa in 1810, when David and Nancy Robinson hired Charles Taylor to construct cabins and a sixty-room hotel on their family's property. Known initially as Yellow Springs, the resort benefited from a popular belief in the restorative powers of mineral waters and catered to a new leisure class seeking healthy and entertaining diversions. In doing so, the resort joined such other nearby establishments as the Greenbrier White, Old Sweet, and Montgomery White Sulphur Springs.

The resort passed through a series of owners (Charles Taylor, 1812; Armistead Forrest, 1842; Foulkes, Gardner and Edmundson, 1853; John and James Wade, 1871) throughout the nineteenth century. In 1852, the resort's name was changed to Yellow Sulphur Springs. The Yellow closed during the Civil War, but re-opened in 1868 to heightened popularity. A second, larger hotel was built in 1871, but was destroyed by fire in 1873. In 1886, Ridgeway Holt acquired the property; he rebuilt the second hotel in 1888.

Easy access to the nearby Virginia-Tennessee Railroad ensured the springs' success. Though not one of the larger spas, the resort could house as many as 400 guests in its hotel and adjacent cottages. Offering such amenities as a ballroom, a billiard room, a bowling alley, and a gazebo, the resort attracted visitors from throughout the United States and several foreign countries. Former Confederate generals Jubal Early and P. G. T. Beauregard each had rooms permanently reserved for their stays. The hotel became a favorite place for students at Virginia Agricultural and Mechanics College (later Virginia Polytechnic Institute and State University) after the college's founding in 1872.

With the advent of the automobile and scientific skepticism of the value of spring baths, however, the popularity of such resorts began to decline by the early twentieth century. The economic panic of 1893 hastened the resort's decline. In 1914, the resort was bought by W.S. Carroll of Lynchburg, who sold it again to W.E. Hazlewood in 1915. Hazlewood owned and operated the resort until about 1923. Many histories report this as the year the resort closed for good, but the property was purchased by a group of African American businessmen from Roanoke, VA in 1926. They reopened the resort the same year and operated it until about 1929. The resort property was reportedly sold by auction in 1929. They operated under the name "Yellow Sulphur Springs, Inc." or "Yellow Sulphur Springs Company." In 1929, after purchasing the property, Charles A. Crumpacker sold much of the personal belongings on the grounds, such as furniture and art. During the Great Depression, the Virginia Transit Bureau leased the resort as a camp for transients, who engaged in restoring the buildings and grounds. In 1943, Charlsie Crumpacker inherited the resort, working on restoring it for 50 years until her death in 1994.

The original hotel and several other buildings remain standing today (2004), having been placed on the National Register of Historic Places in 1979. The buildings have been partially restored, and a guest house and healing arts studio now operate there.