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The collection contains a bill detailing medical service provided to the family of Rev. William A. Wade by Dr. Harvey Black. The bill includes the cost of services, as well as a note from Black forgiving payment.

This collection contains the papers and artifacts of an interrelated family prominent in Blacksburg's history. It includes the American Civil War letters of Confederate surgeon Dr. Harvey Black, the Civil War diary of hospital steward John S. Apperson, cotton books and correspondence of Germanicus Kent, nineteenth-century account books of a Blacksburg general store, 1912 European travel diary, and the political scrapbooks of State Senator and Attorney General Harvey B. Apperson.

The collection consists of receipts, bills, Promissory notes, tax notes, letters, and other various papers created between 1825 and 1912 by members of the Brown, and other related families.

This collection contains an account book of Dr. Robert Thadeus Ellett, a physician residing and practicing in Montgomery County, Virginia during the latter 19th century. The account book includes patient names, dates of visits, and fees.

This collection contains the photographs of Earl Palmer, an award-winning photographer from Cambria, Virginia, whose work depicted the landscape and traditional culture of rural Appalachia in Kentucky, North Carolina, Tennessee, Virginia and West Virginia. Materials date frome 1880 to 1989, but are primarily from the 1940s to the 1970s. The collection is divided among the following series: photographs, duplicate photographs, written materials, oversize photographs, and artifacts.

The collection consists of letters written mostly by Isaac White (1837-1889) to his wife, Mary Virginia "Jinnie" Day White, while he served with the Confederate Army as an assistant surgeon during the American Civil War. Many of the letters are written while encamped along the Shenandoah Valley. Other papers include literature gathered by Bess Duvall White Snead, White's grand-daughter, in her search for military information about Isaac White.