In general, vertical files at Special Collections and University Archives include newspaper clippings, photocopies, ephemera, unpublished and/or informal publications, and other papers relating to a specific subject area. Files in this collection relate to individuals and families connected to the local area (Blacksburg, Montgomery County, and Southwest Virginia) and/or to Virginia Tech. Each individual/family below has at least one folder and many include cross references.

The photograph collection at Special Collections and University Archives consists primarily of historical photographs of Virginia Tech, dating back to the 1890s. The collection is also home to historic images of Blacksburg, Montgomery County, the New River Valley, and Southwest Virginia in general. A photograph collection of faculty and staff from the university is maintained separately.

The John Murray Papers document the participation of John Murray, a Virginia Tech chemistry professor from 1942 to 1971, in Virginia's ornithological community. Collected materials include manuscript articles, scholarly correspondence, and bird watching logs which focus largely on Montgomery County, Virginia.

The Named/Individual Photograph Collections include images from alumni and former faculty and staff, or individuals with ties to campus and the New River Valley. Collections (c.1890-present) depict campus life and events, railroad history, agricultural extension research, Blacksburg and surrounding areas, and some local families.