The collection is arranged into seventeen series by correspondent. Some series have subseries as described below. Within each series or subseries, the items are arranged in chronological order.

• Fletcher Roland Rice, Sr. Papers includes two subseries:
  • Personal Correspondence
  • Business Papers: Many of the business papers are related to the homes he owned and rented out on Walker Ave., N.E. in Roanoke
• Georgianna "Anna/Annie" (Jennings) Rice Papers includes letters with her aunt Nannie Gills, cousin William W. Rice, mother Maria Jennings, and a ticket to ride the train for Anna and her daughter Virginia.
• Gracie G. (Baldwin) Rice Correspondence includes letters from Gracie to Nannie Mae and Fletcher.
• Nannie Mae (Rice) Banks Papers contains the bulk of the material in the collection. This series incluces decades of correspondence with family, friends, and businesses. There are two subseries:
  • Personal Correspondence is divided into twenty-seven subseries by primary correspondent:
    • Solomon Gomarh Payne Correspondence is a series of letters between Nannie and Private First Class Payne while he was serving in Europe during World War I.
    • Owen Burton Correspondence consists of two courtship letters from 1918.
    • Andrew Banks Papers includes letters and papers involving Nannie's husband Andrew.
    • Banks Family Papers includes letters and papers involving Andrew's extended family.
    • Harvey Family Correspondence contains correspondence between Nannie and the famliy and descendants of her cousin Valda R. (Jones) Harvey.
    • Miss Frances Papers includes correspondence and financial records involving Nannie's friend Frances Elizabeth Bush.
    • Janet Kednocker Correspondence includes correspondence between Nannie and Molly Janet (Bush) Kednocker and her family.
    • Bush Family Correspondence includes correspondence between Nannie and Howard Muse and Fannie Elizabeth Bush, Howard Lunsford and Juanita Mae Bush, and Howard Lunsford Bush's carer Kathleen Zollman.
    • Evans Family Correspondence includes correspondence between Nannie and George Washington Evans, Geneva Mary (Patterson) Evans, and their daughter Evelyn Ann Evans
    • Patterson Family Correspondence includes correspondence between Nannie and Mary Geneva (Evans) Patterson and her children Margaret, Stanley, and Tony.
    • Mary B. Miller Correspondence includes correspondence between Nannie and Mary B. (Preston) Miller.
    • Glaze Family Correspondence includes correspondence between Nannie and the Glaze family: Voyce, Sudye, Sudye Jr. "Pixie", Patricia, Louise, Francis, and Pallie.
    • Sigmon Family Correspondence includes correspondence between Nannie and Dell and Hester Sigmon.
    • Saunders Family Correspondence includes correspondence between Nannie and the Saunders family: James, Ruth, Carolyn, Lisa, and Toney.
    • Barley Family Correspondence includes correspondence between Nannie and the family of Margie Barley.
    • Driscoll Family Correspondence includes correspondence between Nannie and the Driscoll family: Jim, Mabel, and Edith.
    • Lena McDermett Correspondence includes correspondence between Nannie and Lena McDermett who identifies herself as both "aunt" and "cousin" in letters.
    • Kidd Family Correspondence includes correspondence between Nannie and the family of Franklin and Minnie Kidd.
    • J.R. and Florence Board Correspondence includes correspondence between Nannie and J.R. and Florence Board.
    • William McKinley and Hattie Rice Correspondence includes correspondence between Nannie and William McKinley and Hattie Rice.
    • Pate Family Correspondence includes correspondence between Nannie and Wilbert Thadius and Bertha Pate.
    • Doris W. Broadbent Correspondence includes correspondence between Nannie and Doris W. Broadbent.
    • Margaret Lucas Correspondence includes correspondence between Nannie and Margaret Lucas.
    • Amanda Belle McCaskell Correspondence includes correspondence between Nannie and Amanda Belle McCaskell.
    • Zona Stevens Correspondence includes correspondence between Nannie and Zona Margaret (Jamison) Stevens
    • Blanche Scott Correspondence includes correspondence between Nannie and Blanche Scott.
    • Other Correspondants includes correspondence between Nannie and many correspondants who are represented in the collection by a single letter or greeting card.
  • Business Papers includes various receipts and two documents from the Owls Social Club of Roanoke, Virginia.
• Laura B. (Rice) Watts Correspondence includes letters and cards involving Laura's family.
• Lillie Mary (Rice) Board Papers includes letters, cards, and documents involving Lillie's family.
• Idella (Rice) Day Papers includes letters, cards, and documents involving Idella's family.
• Naymon Eddieray Rice, Sr., Pfc., Correspondence includes three subseries:
  • Great Depression Era Correspondence includes correspondence from 1929-1939, primarily letters from Naymon to his sister Nannie. He uses the aliases "Bobbie Pate" and "CC," and the nickname "Ray" for many of the letters. There is also one letter from Bertha Pate to Nannie about Naymon who was staying with Bertha in New Jersey during this time period.
  • World War II Era Correspondence includes correspondence from 1940-1944. Most of the correspondence is from Naymon to his sister Nannie but there are some letters to other family members. There are some letters from Naymon's first wife, Rebecca F. Kirkland, to Nannie during 1941-1942 and a couple of items from Naymon's second wife Gladys Virginia Watts to Nannie toward the end of 1944.
  • Postwar Correspondence includes correspondence from September 1945-1958. This series includes letters and cards from Naymon and Gladys primarily to Nannie.
• James Cornelius Rice, Pvt., Correspondence includes letters between James and his sister Nannie during World War II.
• Georgianna Maria Wilson Correspondence includes letters and cards involving the family of Georgianna Wilson: Georgianna, Tito, Janet, Dino, and Ortiz.
• James "Jimmy" Lester Rogers, Pvt., Papers includes correspondence between Nannie and her foster son Jimmy during World War II. There are also letters, envelopes, and documents related to Nannie's inquiries about Jimmy after his death while serving in Europe.
• Matthews Family Correspondence includes correspondence with the family of Olivia Lucille (Housier) Matthews.
• Wilson Family Correspondence includes correspondence with the family of Patricia E. Wilson.
• Laura Bell Baldwin Correspondence includes a Christmas card and an invitation to a bridal shower.
• Naymon Jr. and Patricia Rice Correspondence includes correspondence with Naymon Jr.'s family.
• Photographs includes two photographs and one negative.
• Miscellaneous includes a coupon for Colgate Octagon Soap, a decoration made from a postcard, an unsigned note on a scrap of paper a recipe for rhubarb pie, an undated copy of the "Little Blue Book" and two business envelopes.