This collection contains a typescript letter from and about the New River Bulletin, a twenty-eight column weekly in New River Depot, Virginia, in 1885.

This collection conains the records of the Virginia Tech Museum of Natural History. Scrapbooks include newspaper articles, pictures, and flyers all related to the museum and its activities and exhibits. The collection also includes many pictures, slides, brochures, posters, and even a book related to the museum and the people involved.

Photocopy of Cathleen Carlson Reynolds' master's thesis, "A Pragmatic Loyalty: Unionism in Southwestern Virginia, 1861-1865," completed at the University of Alabama at Birmingham in 1987.

This collection contains papers from the Shugart Family of Southwest Virginia, created between 1811 and 1876.

The collection contains project files and drawings related to more than 1,500 residences, churches, businesses, schools, and community buildings, predominantly in the Roanoke and Southwest Virginia area, designed by Smithey & Boynton, mostly between 1935 and 1957.

This collection contains over one hundred photographs from a family that lived in southwest Virginia during the period of 1913 through 1917. Several pictures depict Virginia Tech (VPI) during this period. Other images show the family's travels throughout the American South.

William C. Wampler, Sr. (1926-2012) was a U.S. Congressman from Virginia's 9th District in the 1950s through 1980s. His papers primarily document his tenure in the House of Representatives during the 1970s and 1980s, including correspondence with constituents, committees, and government departments, legislative files, public relations and campaign materials, and photographs.

The collection contains three post-Civil War letters addressed to former Confederate General Gabriel C. Wharton: one regarding potential locations for a blast furnace, one relating to fees for the use of two horses, and one about a petitition on some property in Blacksburg.

This collections contains papers and letters addressed to Henry Whitman, the Justice of the Peace for Wythe County, Virginia, in the mid-1800s. Most documents contain information about different legal dispitutes and issues. Two relate to the purchasing of a bridle and of leather, and another letter relates information about the American Civil War.

This collection contains a telegraph sent from Captain R. A. Williams, A.C.S. [Acting Commissary of Subsistence], in Wytheville, Virginia, to Captain Isaac Shelby in Abingdon asking for advice about an order that required Williams to send four soldiers elsewhere. Williams notes that the order would take "four of my most indispensable men and if persisted in will paralyze my operations".