The collection includes a scrapbook of John Henry Johnson, a Scott County, Virginia politician, including letters signed by other politicians (including William Jennings Bryan and other members of the Bryan family), newspaper clippings, certificates, invitations, original poetry, and a photograph.

The Clyde Kessler Papers include a 1990 list of birds, "Philpott Reservoir Christmas Bird Count," and a list "Butterflies Observed Along the Little River during Summer 1991."

The collection contains an arrest warrant issued on January 30th, 1864 for Patrick Keyces, a deserter from the 30th Virginia Sharpshooters Battalion.

This collection contains newspaper articles, papers, photographs, and posters relating to Madison E. Marye's years as a Virginia State Senator. Marye is a veteran of World War Two, Korea, and Vietnam, serving in the U. S. Army from 1944 to 1965. When Marye retired from the Army he had achieved the rank of Major. After leaving the Army, Marye began his political career representing parts of Southwestern Virginia as a Democrat. Marye served in the State Senate from 1973 to 2002.

Record book documenting baptisms, meeting minutes, memberships, Sunday school attendance, and financial information for the Pulaski, Virginia, Mission of the Methodist Episcopal Church, South.

This collection contains a typescript letter from and about the New River Bulletin, a twenty-eight column weekly in New River Depot, Virginia, in 1885.

This collection conains the records of the Virginia Tech Museum of Natural History. Scrapbooks include newspaper articles, pictures, and flyers all related to the museum and its activities and exhibits. The collection also includes many pictures, slides, brochures, posters, and even a book related to the museum and the people involved.

Photocopy of Cathleen Carlson Reynolds' master's thesis, "A Pragmatic Loyalty: Unionism in Southwestern Virginia, 1861-1865," completed at the University of Alabama at Birmingham in 1987.

This collection contains papers from the Shugart Family of Southwest Virginia, created between 1811 and 1876.

The collection contains project files and drawings related to more than 1,500 residences, churches, businesses, schools, and community buildings, predominantly in the Roanoke and Southwest Virginia area, designed by Smithey & Boynton, mostly between 1935 and 1957.